Author

Romane Riou

Lyon 1 UniversitéORCID 0000-0002-2345-8503Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Bénédicte F. PyiD· 2 shared Matthias GeyeriD· 2 shared A. DuquesneiD· 1 shared Aditi DeshpandeiD· 1 shared Alexander N.R. WeberiD· 1 shared Alexandre BélotiD· 1 shared Alexandre Thibault Jacques MariaiD· 1 shared Amaury ReyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Bénédicte F. PyORCID

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2 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedJul 24, 2025

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

Kevin Wilhelmsen, Aditi Deshpande, Sarah U. Tronnes…·Rebecca C. Coll

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

21 citationstop 2%

humanmouse

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ImmunologyThe Journal of Experimental MedicinePeer-reviewedFeb 28, 2024

Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.

Camille Cosson, Romane Riou, Danish Patoli…·Bénédicte F. Py

This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.

56 citationstop 2%

humanexperimental assay

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