Author

Michael A. Wheeler

Broad InstituteORCID 0000-0002-0689-6384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1

Frequent Co-Authors

Alexandre PratiD· 2 shared Camilo Faust AkliD· 2 shared Francisco Javier QuintanaiD· 2 shared Gavin PiesteriD· 2 shared Hong‐Gyun LeeiD· 2 shared Iain C. ClarkiD· 2 shared Jack Perry AnteliD· 2 shared Joon-Hyuk LeeiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alexandre PratORCID

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3 papers

Recent·Most cited

Systems BiologyTranslational PsychiatryPeer-reviewedNov 29, 2025

Integrative systems neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder

Haroldo Dutra Dias, Anny Silva Adri, Adriel Leal Nóbile…·Otávio Cabral-Marques

This study identifies PAX6 as a critical predictor of MDD using transcriptomic data from 3,114 individuals and validates its expression in PBMCs and the amygdala.

3 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintMay 30, 2025

Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples

Hong‐Gyun Lee, Zhaorong Li, Camilo Faust Akl…·Francisco Javier Quintana

The paper rebuts claims that astrocyte epigenetic memory is due to immune cell contamination, showing its existence in pure astrocyte cultures and MS samples.

2 citations

humanscRNA-seq

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ImmunologyNaturePeer-reviewedMar 20, 2024

Disease-associated astrocyte epigenetic memory promotes CNS pathology

Hong‐Gyun Lee, Joseph M. Rone, Zhaorong Li…·Francisco Javier Quintana

This study identifies an epigenetically controlled memory astrocyte subset that exacerbates CNS pathology in EAE and MS by promoting pro-inflammatory responses.

139 citationstop 1%

mousescRNA-seq

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