Jack Perry Antel

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

The paper investigates how epigenomic factors like chromatin accessibility and histone modifications affect human oligodendrocyte myelination and age-related vulnerability to injury.

This study shows that dPGA-coated substrates support longer-term mixed glial cultures, enabling repeated isolation of immature oligodendrocyte lineage cells compared to PDL-coated substrates.

The paper rebuts claims that astrocyte epigenetic memory is due to immune cell contamination, showing its existence in pure astrocyte cultures and MS samples.

This study shows that TNF and IFNγ inhibit human OPC differentiation into oligodendrocytes and promote an astrocyte-like reactive phenotype, potentially contributing to impaired myelin repair in MS.

The paper uses single-cell RNA sequencing to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures and characterizes their differentiation response.

The paper identifies four subpopulations of human choroid plexus epithelial cells, including TYRP1-high cells with distinct molecular features related to pigmentation, cell cycling, and stress.

This study identifies immune gene expression signatures in neurons from MS patients and EAE mice, revealing shared pathways and potential roles for IRF5 and STAT1 in neuronal inflammation.

This study identifies an epigenetically controlled memory astrocyte subset that exacerbates CNS pathology in EAE and MS by promoting pro-inflammatory responses.

The paper develops a SOX10 reporter system to improve the differentiation of oligodendrocytes from iPSCs, enhancing reproducibility and maturity.

This study creates a cell atlas of the adult human subventricular zone using single-cell transcriptomics, identifying multipotent neural stem cells and their lineage potential.

The paper optimizes an iMGL protocol to generate microglia-like cells from an ALSP patient, revealing functional defects in migration and phagocytosis.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

The paper compares culture media effects on human microglia, finding that serum supports key genes and phagocytic function, while CSF1R signaling reliance decreases in culture.

The paper shows MS-derived oligodendroglia can myelinate axons and form functional connections in a mouse model, suggesting the differentiation block is due to environmental factors, not intrinsic deficits.

The paper investigates altered expression and mislocalization of RNA-binding proteins TDP-43 and PTB in multiple sclerosis lesions and cultured oligodendrocytes, linking them to demyelination and neurodegeneration.

This paper develops a deep learning method to quantify oligodendrocyte ensheathment in vitro, achieving accuracy comparable to human experts and enabling high-throughput analysis.

This study shows that 7nAChR agonists reverse LPS-induced pro-inflammatory microglial phenotype in fetal sheep, while antagonists enhance it, suggesting therapeutic potential for neuroinflammation.