Rachel M. Guerra

This study maps the interactomes of pathogenic SCO1 and SCO2 variants using BioID, revealing their roles in copper delivery and phospholipid metabolism disruption.

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

This study shows RTN4IP1 is critical for mitochondrial complex I assembly and coenzyme Q biosynthesis, with mutations causing defects in both processes in patient cells.

The paper identifies Fmp30 as a phosphatidylinositol hydrolase that negatively regulates CoQ biosynthesis in yeast by affecting lipid metabolism.

The paper identifies genes and metabolic regulators of nucleotide synthesis using uridine salvage and CRISPR-Cas9 screening, revealing NUDT5's role in maintaining nucleotide balance and its impact on chemotherapy resistance.