ImmunologybioRxivPreprint
In vivo CRISPR-based screen identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors
Paula Barbao, Alba Rodríguez-García, Ariel Galindo‐Albarrán…·Sònia Guedan
The paper identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors through an in vivo CRISPR screen and validates its role using single-cell RNA and ATAC-seq.