Rodrigo S. Lacruz

This study shows that increased mitochondrial metabolism in Down syndrome iPSCs impairs neuroectoderm commitment by reducing ciliation, and this effect can be reversed by inhibiting mitochondrial calcium uptake.

This study identifies NCKX4 as a key regulator of vascular aging, showing its decline accelerates aortic remodeling and calcification in aged mice, particularly in females.

This study identifies Treg cells and IFN-γ-producing Th1 cells as key drivers of Sjögren's Syndrome pathogenesis using a mouse model and single-cell transcriptomics.

This study uses single-cell transcriptomics to identify altered activation states of B and T lymphocytes in Sjogren's Disease patients compared to controls.

This study shows that loss of STIM1 and STIM2 in salivary glands reduces ANO1 function and saliva production but does not cause Sjogren's disease, suggesting a link between SOCE and TLR8 signaling.