Chance John Luckey

This study shows that RBC transfusion induces weak IgG class switching compared to vaccination, due to suboptimal T cell help, and activates T cells via a non-canonical pathway.

This study develops an engineered human lymph node stroma model to examine how interstitial fluid flow affects T cell egress and stromal cell behavior.

This study shows that male sex-specific anti-angiogenic effects of hIgG1 depend on the Y chromosome-encoded DDX3Y gene, revealing a mechanism for sex differences in AMD.

This study shows splenic MARCO+ marginal zone macrophages (MZMs) enhance cytokine production but are not required for anti-RBC alloantibody generation after stored RBC transfusion in mice.

This study develops an in vitro lymph node microphysiological system to model early T cell-B cell interactions and antibody responses using primary human lymphocytes.

This study shows that reducing reactive oxygen species and increasing hydrogel porosity improves cell viability and function in photocrosslinked gelatin-thiol hydrogels.