Author

Sergio Grinstein

University of TorontoORCID 0000-0002-0795-4160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

Spencer A. FreemaniD· 2 shared Amir MohamediD· 1 shared Amra SarićiD· 1 shared Bo Wen Pang· 1 shared Brian RaughtiD· 1 shared Étienne CoyaudiD· 1 shared Iris Li· 1 shared Iuliia FerlingiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

Spencer A. FreemanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 14, 2025

Lipid scrambling via TMEM16F mediates the formation and release of apoptotic vesicles

Trieu Le, Yu Meng Li, Amra Sarić…·Spencer A. Freeman

This study shows that TMEM16F-mediated lipid scrambling drives the formation and release of apoptotic-like vesicles without affecting cytosolic calcium or the cytoskeleton.

DOI 10.1101/2025.05.14.654002

experimental assaycell signaling & trafficking

𝕏 PostBluesky

Cell BiologybioRxivPreprintJan 31, 2024

Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators

Iuliia Ferling, Steffen Pfalzgraf, Lea Moutounet…·Spencer A. Freeman

This study shows that reactive oxygen species (ROS) from IgG-opsonized targets suppress phagocyte surveillance by oxidizing cytoskeletal regulators, leading to cell compaction and podosome disassembly.

2 citations

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

Cell BiologybioRxivPreprintJan 12, 2024

Adenomatous polyposis coli (APC) regulates internalization and signaling of the chemorepellent receptor, Roundabout (ROBO) 1

Yiwei Huang, Jonathan R. St‐Germain, Bo Wen Pang…·Lisa Annette Robinson

This study identifies APC's role in SLIT2-induced ROBO1 endocytosis and its impact on cell morphology.

1 citation

proteomicsexperimental assay

𝕏 PostBluesky