Jonathan R. St‐Germain

This study identifies S-palmitoylation as a reversible regulatory mechanism for GDH, affecting its quaternary structure and enzymatic activity through cysteine modifications.

The paper identifies Sec23b as a regulator of cell migration by controlling collagen I secretion and processing through a proteomic-based assay.

This paper introduces ProtacID, a BioID-based method to identify PROTAC-proximal proteins, validates degradation targets, and identifies non-productive interactions in human cells.

This study uses cryo-EM to show AKAP350 forms fibrillar clusters and interacts with DNA and DNA-binding proteins like NFIB and NCL.

The paper identifies RAD54L2 as a regulator of recombination by showing its interaction with the BTRR complex and its role in suppressing sister chromatid exchanges.

The paper identifies TBPL1 and PAF1 as regulators of Pol II at the intergenic spacer (IGS) of rDNA, showing their role in controlling Pol I activity and maintaining nucleolar structure and rRNA biogenesis.

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

This study identifies APC's role in SLIT2-induced ROBO1 endocytosis and its impact on cell morphology.

This study identifies how SLAP2 binding to CBL disrupts its autoinhibition, revealing a mechanism for activating CBL's ubiquitin ligase function.

Proximity-dependent biotinylation of 27 SARS-CoV-2 proteins in A549 cells maps 7810 virus-host proximity interactions across 2242 host proteins, including membrane-associated partners missed by affinity purification.