ImmunologybioRxivPreprint
The human immune checkpoint molecule, HLA-G2, induces tolerance in monocytes and dendritic cells via upregulation of PD-L1
Ami Takahashi, Kimiko Kuroki, Naoyoshi Maeda…·Katsumi Maenaka
This paper shows HLA-G2 induces tolerance in human monocytes and dendritic cells by upregulating PD-L1 through LILRB2 binding, suggesting it as a target for immune checkpoint therapy.
DOI 10.1101/2023.10.14.562373