Alastair W. Poole

This study characterizes recombinant disintegrins from Echis species, showing distinct inhibitory effects on platelet aggregation and endothelial cell migration.

This study investigates the roles of disintegrin-like and cysteine-rich domains in substrate recognition and catalytic activity of PIII snake venom metalloproteinases using recombinant variants and functional assays.

This paper shows that NX-5948, a BTK degrader, reduces thrombosis without affecting haemostasis by selectively degrading platelet BTK.

The paper develops a method to produce and activate purified snake venom metalloproteinases (SVMPs) using recombinant zymogens, enabling detailed biochemical and functional analysis.

The paper uses cryoET to show cofilin-bound F-actin within platelet microtubules, revealing physiological actin-microtubule hybrids formed under mechanical stress.