Mark P. Dodding

The paper identifies a phosphorylation-dependent gate on kinesin-1 activity mediated by KLC2 CTD, revealing a kinase-kinase code that regulates lysosome transport through adaptor binding and membrane cues.

This study shows that cargo-sensitive TPR switch in kinesin-1 controls its conformational dynamics by dislocating the TPR shoulder, promoting motor domain activation and microtubule binding.

The paper uses cryoET to show cofilin-bound F-actin within platelet microtubules, revealing physiological actin-microtubule hybrids formed under mechanical stress.

The paper engineers an allosteric switch in kinesin-1 motors using de novo peptides, showing increased transport in cells through conformational changes.

The paper designs a high-affinity peptide (KinTag) that hijacks microtubule-based transport by binding KLCTPRs with nanomolar affinity, enhancing cargo transport efficiency.