Vineethkrishna Chandrasekar

This study shows that chemotherapy, specifically CarboTaxol, synergizes with cancer vaccines and anti-PD-1 to improve tumor control and survival by expanding stem-like TCF1+CD8+ T cells.

The paper introduces PerturbPair, a platform integrating transcriptomic and optical screens to map macrophage regulatory networks, revealing cross-modal relationships and disease-relevant gene programs.

This paper develops a method to isolate and characterize SMAPs from NK-92 cells, showing their cytotoxic activity against tumor cells in vitro and in vivo.

SpatialAgent integrates large language models with dynamic tool retrieval, multimodal interpretation, and claim verification to automate end-to-end spatial biology workflows from gene-panel design to tissue annotation and hypothesis generation.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.