Nadine Fernandez-Novel Marx

This study shows that H3.3K9 and K27 modifications regulate repressive chromatin states at cis-regulatory elements and bivalent promoters in mESCs, affecting gene expression.

This study shows that mouse brain lipotypes develop in two stages, with cholesterol increasing postnatally, and that stem cell-derived neurons do not fully recapitulate this lipotype.

The paper identifies gene regulatory network disruptions caused by LSD1 mutations in early differentiation, showing impaired transcription factor activity and potential therapeutic targets through HDAC inhibition.