Fabiana Perocchi

This study identifies the MCUR1-CCDC90B complex as a mitochondrial scaffold regulating metabolic homeostasis, showing its role in amino acid metabolism and linking its deficiency to neurometabolic disease.

This study maps the MCU-mediated mitochondrial calcium signaling network using proteomics, identifying 89 new interactors and their roles in disease-related pathways.

The paper shows that TCA cycle dysfunction contributes to axonal energy deficiency in neuroinflammatory lesions and that restoring TCA enzymes can alleviate this deficit.

The paper shows that Pink1 mRNA is transported with mitochondria and tethered by SYNJ2BP and SYNJ2 to support local mitophagy in neurons.

mitoXplorer is a web-based platform that integrates and visualizes mitochondrial gene expression and mutation data across multiple datasets to uncover regulatory differences in mitochondrial dynamics.

This study shows MICU1 is essential for MCU ion selectivity and protects cells from manganese toxicity.