Claudia Cicala

This study identifies IL-6 as a key factor in the differentiation of naive CD4+ T cells into gut tissue resident memory T cells (TRMs) through a combination of MAdCAM-1, TGF-β, and RA signaling.

TGF-β blockade with galunisertib reverses SIV latency, reduces viral reservoirs, and enhances immune responses in ART-treated macaques without systemic inflammation.

This study shows that combining VRC01 and Rh-4β7 antibodies delays SHIV infection, preserves CD4+ T cells, and alters immune responses in macaques.