Laura Tronci

The paper identifies FADS1/2-mediated lipid metabolic reprogramming as a driver of ferroptosis sensitivity in triple-negative breast cancer, showing that high FADS1/2 expression correlates with poor prognosis and susceptibility to ferroptosis-inducing agents.

This study shows that inhibiting asparagine synthetase (ASNS) with antisense oligonucleotides reduces kidney volume and improves renal function in PKD mice by targeting metabolic pathways.