PhysiologyJCI InsightPeer-reviewed
Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function
Jessica B. Sarthi, Annie M. Trumbull, Shayda M. Abazari…·Zachary M. Sellers
This study shows linaclotide stimulates bicarbonate secretion in CFTR-deficient tissues by enhancing DRA expression, suggesting DRA as a therapeutic target for CF-related intestinal dysfunction.