GeneticsPLoS GeneticsPeer-reviewed
A genome-wide CRISPR screen identifies the glycosylation enzyme DPM1 as a modifier of DPAGT1 deficiency and ER stress
Hans M. Dalton, Raghuvir Viswanatha, Roderick Brathwaite…·Clement Y. Chow
The paper identifies DPM1 as a therapeutic target for DPAGT1-CDG by showing its inhibition rescues ER stress and glycoprotein levels in Drosophila models.
17 citations