Geming Lu

This study shows that harmine plus exendin-4, when combined with anti-CD3 therapy, promotes beta-cell recovery and reduces immunogenicity, leading to remission of recent-onset type 1 diabetes.

This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.

This study identifies human α-cell and β-cell subtypes and trajectories using integrated scRNA-seq and snRNA-seq, revealing gene signatures for interconversion and highlighting in vivo transitions in T2D.

This study uses single-cell RNA sequencing to identify cycling alpha cells as key beta cell progenitors in response to DYRK1A inhibitor treatment in human pancreatic islets.