BiochemistryeLifePeer-reviewed
Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism
Bernd K. Gilsbach, Franz Y. Ho, Benjamin Riebenbauer…·Christian Johannes Gloeckner
This study identifies a kinase-dependent negative feedback mechanism regulating LRRK2 Roc G domain activity through autophosphorylation of T1343, affecting GTP hydrolysis kinetics.
8 citations