Cristina Herencias

This study identifies multireplicon plasmids in bacterial genomes, showing they are common, gene-rich, and shaped by predictable fusion rules that influence AMR spread.

This paper isolates and characterizes viable Bdellovibrio from human fecal samples, revealing genomic conservation and prey specialization in the human gut microbiome.

The paper shows plasmid mutation rates increase logarithmically with copy number, outpacing segregational drift, enhancing bacterial evolvability.

The paper investigates plasmid-chromosome transcriptional interactions in multidrug-resistant bacteria, finding that a plasmid-encoded regulator drives chromosomal operon overexpression, enhancing bacterial fitness and carbapenem resistance dissemination.

This study shows plasmid-encoded insertion sequences (IS1) enhance bacterial adaptation by increasing gene inactivation rates in clinical enterobacteria.

This study shows Bdellovibrio bacteriovorus can grow without prey using amino acids as carbon sources, revealing their metabolic flexibility and potential for biotechnological applications.

This study shows that β-lactamase expression in E. coli induces collateral sensitivity to colistin and azithromycin, suggesting a therapeutic strategy to counter mobile AMR.

This paper constructs a genome-scale metabolic model of Bdellovibrio bacteriovorus to analyze its growth-phase dependent metabolic states and provides insights into its biphasic lifestyle and metabolic robustness.