Thomas Burke

This study identifies cyclophilin A as a host factor critical for the maturation and function of a virulence factor in obligate intracellular bacteria, with implications for therapeutic targeting.

This study compares seven strains of Orientia tsutsugamushi to identify virulence factors, finding no single gene or pattern predicts virulence, but highlighting complex interactions among effector proteins.

The paper identifies differences in nitric oxide production between human and rodent macrophages as a key factor in susceptibility to tick-borne Rickettsia.

This study shows that combining STING and TLR agonists enhances anti-tumor effects in mice, with synergistic responses observed when using bacterial pathogens and small molecule TLR agonists.