Timon Heide

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

This paper introduces a model-based subclonal reconstruction method that integrates evolutionary theory with machine learning to improve accuracy in tumor subclonal analysis.

This paper shows that spatial tumour structure affects mutation patterns in sequencing data and introduces a framework to account for these effects in cancer genomic analysis.

The paper responds to criticism of a method used to infer neutral cancer evolution from variant allele frequency distributions, arguing that neutral evolution explains intra-tumour heterogeneity in some cancers.