Author

Huanhuan Joyce Chen

University of ChicagoORCID 0000-0002-1446-7184Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Abhimanyu ThakuriD· 1 shared Chen ZhangiD· 1 shared Eric E. GardneriD· 1 shared HAROLD E. VARMUSiD· 1 shared Kui ZhangiD· 1 shared Olivier ElementoiD· 1 shared Yajas ShahiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abhimanyu ThakurORCID

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1 paper

Recent·Most cited

Cancer BiologyeLifePeer-reviewedJan 19, 2024

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

Huanhuan Joyce Chen, Eric E. Gardner, Yajas Shah…·HAROLD E. VARMUS

This study shows that overproducing cMYC in TP53 and RB1-depleted hESC-derived PNECs leads to aggressive SCLC-like tumors with metastatic properties and NEUROD1 expression.

12 citations

humanbulk RNA-seq

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