Author

HAROLD E. VARMUS

Weill Cornell MedicineORCID 0000-0002-6444-1943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Eric E. GardneriD· 2 shared Abhimanyu ThakuriD· 1 shared Antonino MontalbanoiD· 1 shared Arun M. UnniiD· 1 shared Chen ZhangiD· 1 shared Huanhuan Joyce CheniD· 1 shared Jerin ThomasiD· 1 shared John BlenisiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Eric E. GardnerORCID

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2 papers

Recent·Most cited

Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewedMay 14, 2024

LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase

John R. Ferrarone, Jerin Thomas, Arun M. Unni…·HAROLD E. VARMUS

This study identifies LKB1's role in suppressing growth by activating PIKFYVE to promote EGFR internalization in LUAD.

11 citations

humangenetic perturbation / CRISPR

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Cancer BiologyeLifePeer-reviewedJan 19, 2024

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS

Huanhuan Joyce Chen, Eric E. Gardner, Yajas Shah…·HAROLD E. VARMUS

This study shows that overproducing cMYC in TP53 and RB1-depleted hESC-derived PNECs leads to aggressive SCLC-like tumors with metastatic properties and NEUROD1 expression.

12 citations

humanbulk RNA-seq

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