Andrzej Antoni Szczepankiewicz

This study identifies Arc/Arg3.1 as a regulator of PABPN1 nuclear speckles through direct binding, impacting mRNA processing during neuronal activity.

This study shows neuronal activation remodels nuclear speckles' organization and protein composition in rat hippocampal neurons without causing stress or cell death, and these changes depend on transcription and splicing.

The paper identifies OMA1 protease as a key factor in resolving arrested protein import intermediates in human cells through mitochondrial membrane depolarization.

The paper investigates the relationship between Bdnf transcription and histone acetylation in epilepsy, finding that Bdnf repositioning correlates with epileptic traits and is influenced by transcriptional activity and histone deacetylase inhibition.

This paper develops a new electron microscopy method to visualize 3D chromatin folding at ultra-resolution in human cells and finds high heterogeneity in chromatin structures.