ImmunologyiSciencePeer-reviewed
RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury
Jagdish Chandra Joshi, Bhagwati Joshi, Cuiping Zhang…·Dolly Mehta
This study shows RGS2 limits IFNγ production in alveolar macrophages by inhibiting TLR4-Gαq signaling, reducing lung injury in mice and correlating with ARDS patient data.
14 citations