Murad R. Mamedov

This study finds that higher pretreatment γδ T-cell abundance is linked to better outcomes in cancer patients receiving immune checkpoint blockade and improved survival across multiple tumor types.

The paper develops a non-viral method using hybrid ssDNA repair templates to improve genome engineering in primary human cells, achieving high knock-in efficiency and cell yields for disease modeling and cell therapy.

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.