Alcino J. Silva

The paper investigates acute rapamycin treatment in a maternal inflammation mouse model of autism, showing rapid rescue of behavioral and functional dysfunctions linked to mTOR pathway activation.

The paper describes an open-source miniature 2-photon microscope for recording calcium dynamics in freely behaving mice during various experimental conditions.

This study identifies intercellular signaling pathways involved in vascular dementia repair and demonstrates therapeutic potential through drug intervention.

This study identifies a dual amygdala-striatal pathway architecture by which chronic stress disrupts agency and promotes habit formation in mice.

The paper introduces a miniature microscope for high-resolution neural imaging in freely behaving rats, capable of imaging over 1000 neurons in the hippocampus and 2000 in the cortex.

This study shows that strong aversive experiences in mice drive offline reactivation of both recent aversive and older neutral memories, linking them across days.

The paper identifies a locus coeruleus-dorsal CA1 dopaminergic circuit that modulates memory linking without affecting memory formation.

This paper shows that delayed CCR5 expression after memory formation limits the temporal window for linking memories by reducing neuronal overlap in mice.

This study shows that microglia and type I interferon signaling contribute to memory and long-term potentiation deficits in male Tsc2+/- mice, which can be reversed by microglia depletion or interferon receptor manipulation.

The paper shows that memory allocation across brain regions is coordinated through a retrograde mechanism, demonstrated by manipulating memory in the basolateral amygdala and observing effects in the insular cortex.

The paper shows that dendritic plasticity in the retrosplenial cortex links memories by allocating spine clusters to the same dendritic segments for temporally close memories.

This study identifies the dorsal premammillary nucleus as a central node in the escape network by showing its role in controlling escape vigor from both innate and conditioned threats in mice and suggesting a similar pathway in humans.

This study investigates spatial coding and neural synchronization in epilepsy using in vivo calcium imaging and network modeling, finding impaired spatial processing and desynchronized firing in epileptic mice.

The paper identifies a spatiotemporal dynamic network in the brain associated with depression vulnerability using machine learning and LFP data from stressed mice.