Rafael P. Vázquez‐Manrique

The paper restores dystrophin expression in DMD cells by replicating a specific exon deletion and creates a new cell model to study the mutation's effects.

The paper shows that UNC-1 in C. elegans neurons modulates protein homeostasis by altering fat metabolism through neurohormonal signaling involving NHR-1 and DAF-12.

The paper presents a CRISPR-mediated method for inducing genetic changes in hematopoietic cells using PCR-generated constructs, showing comparable efficiency to ribonucleoprotein strategies without off-target effects.

This study shows that loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation in C. elegans and other organisms.