Lothar Schermelleh

This study shows cohesin maintains condensed euchromatic domains in human cells by preventing local mixing, which is crucial for transcriptional insulation.

This paper identifies Ab-trapping as a staining artifact in antibody-based techniques, showing it results from high epitope abundance, high Ab affinity, and low diffusion rates, and suggests mitigation strategies.

This study shows Xist RNA localizes to A1-sub-compartments on the X chromosome, which are positioned peripherally in compacted chromosome territories.

The paper shows that slowing RNAPII elongation during cell state transitions enhances naive pluripotency acquisition while maintaining replication fork speed.

Shape2Fate tracks and classifies exocytic and endocytic carriers in live cells using morphology-aware deep learning, revealing pathway-specific exo-endocytic coordination rules.

This paper introduces Deep3DSIM, an upright 3D-SIM system with adaptive optics for deep tissue imaging, achieving high-quality imaging up to 130 micrometers in Drosophila brain.

The paper visualizes Xist RNA dynamics in single cells during X chromosome inactivation using time-resolved structured illumination microscopy.

The paper shows that cold exposure causes chromatin compaction and nuclear retention of circadian clock transcripts, which resets the circadian rhythm upon rewarming.

The paper identifies linked chromatin domains (CDs) with nanoscale functional topography in somatic cells, showing cohesin and histone modifications are confined to surfaces and enriched in cores, independent of cohesin.