Tinkering loci: hubs of gene birth in an animal genome
The paper identifies 'tinkering loci' in Drosophila genomes that accelerate gene birth by concentrating duplicated gene fragments and facilitating composite gene creation.
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Princeton UniversityORCID 0000-0002-1648-6776Unclaimed ORCID profile · follow to get notified of new preprints
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The paper identifies 'tinkering loci' in Drosophila genomes that accelerate gene birth by concentrating duplicated gene fragments and facilitating composite gene creation.
The paper identifies exon shuffling hotspots in Drosophila affinis genomes, showing they facilitate rapid gene creation and family formation through genomic sequence rearrangement.
Daniel P Higgins, Caroline M. Weisman, Dominique S. Lui…·Amy Karol Walker
WormCat 2.0 identifies poorly annotated genes in C. elegans and shows they have human orthologs with limited annotation.
Caroline M. Weisman, Andrew W. Murray, Sean R. Eddy
The paper shows that using different gene annotation methods in comparative genomics can falsely increase the number of lineage-specific genes by up to 15-fold.