M. Groll

This paper designs de novo ligases that achieve site-specific ubiquitylation of a target protein with high selectivity and efficiency.

The paper identifies xildivaline, a novel peptide deformylase inhibitor produced by Gammaproteobacteria, and elucidates its biosynthesis and structural features.

This study identifies and characterizes XrdM, an amide methyltransferase involved in dithiolopyrrolone antibiotic biosynthesis, and shows it is distinct from DtpM in structure and function.

The paper describes an evolution-inspired method to engineer NRPS by identifying a recombination breakpoint and using it to assemble NRPS fragments for producing a proteasome inhibitor.