Markus Sauer

The paper develops a normative model to show that transsynaptic nano-architecture optimizes postsynaptic current amplitude and minimizes delay during multivesicular release at the Drosophila NMJ.

The paper introduces Mega-expansion microscopy, a fluorescence imaging technique that enables high-resolution structural visualization of whole cells using conventional microscopes.

This paper introduces programmable protein standards for benchmarking sub-10-nm fluorescence microscopy, demonstrating their utility in assessing fluorophore interactions and imaging performance.

This study shows that M-CSF enhances alveolar macrophage function to protect against invasive aspergillosis in immunocompromised mice.

This study identifies sphingolipids, specifically sphingomyelin, as key molecules involved in DNA condensation and developmental regulation in Chlamydia trachomatis.

The paper combines expansion microscopy with two-dye-imager DNA-PAINT to achieve nanometer-resolution 3D imaging of expanded cells.

This paper introduces FluoroCubes as fiducial markers for traction force microscopy, enabling high-resolution force mapping with improved sensitivity and compatibility with TIRF microscopy.

This paper introduces a single-step expansion microscopy method enabling SMLM with spontaneously blinking dyes in expanded samples, achieving nanometer-resolution imaging of cellular structures.

The paper develops an optimized immunolabeling protocol to quantify endogenous membrane receptor stoichiometry using single-molecule localization microscopy on Jurkat T cells and primary multiple myeloma cells.

This paper develops a geometric deep learning framework for improved particle averaging in single-molecule localization microscopy, achieving comparable results to state-of-the-art methods without explicit 3D alignment.

NanTex enables multiplexing and phenotyping of organelles using nanotexture descriptors from single-channel super-resolution microscopy data across multiple modalities.

The paper develops an optimized Ex-dSTORM method to resolve endogenous protein assemblies with nanometer precision in cells.

The paper improves single-molecule localization microscopy by extending temporal context using a hybrid U-Net and Transformer model, achieving better resolution than existing methods.

This study compares patient-specific stem cell models of RBM20 mutations causing dilated cardiomyopathy and left ventricular non-compaction, identifying distinct molecular, cellular, and functional impairments.

The paper develops TDI-DNA-PAINT and LLS microscopy to study CD20-rituximab interactions in B cells, revealing oligomeric states and polarization effects.

This study investigates how LGI1 autoantibodies enhance synaptic transmission by reducing Kv1 channel density and broadening presynaptic action potentials.

The paper investigates the interaction between human keratinocytes and nerve fibers at the neuro-cutaneous unit using advanced imaging techniques and a co-culture system.

This study creates a neuronal in vitro model of Fabry disease to investigate small fibre neuropathy mechanisms, finding Gb3 accumulation, altered ion channel function, and mitochondrial trafficking issues.

This study shows that SARS-CoV-2 uses monomeric ACE2 receptors for infection, with single S protein interactions sufficient for entry.

The paper uses endogenous tagging to study Unc-13 nanocluster reorganization during presynaptic homeostatic potentiation in Drosophila.

The paper uses super-resolution microscopy to show that dopamine transporter (DAT) in neurons exists in dynamic nanodomain and unclustered configurations, regulated by excitatory drive and D2-autoreceptor activity.

The paper introduces ReCSAI, a compressed sensing neural network for confocal dSTORM that improves reconstruction speed and accuracy by combining deep learning and compressed sensing.

The paper investigates dynamic remodeling of endoplasmic reticulum and ribosomes in axons of motoneurons in response to BDNF stimulation, revealing their role in local translation and synapse maintenance.

ShareLoc provides an open platform for sharing and reanalyzing SMLM data to enhance image reconstruction through deep learning.

The paper develops a method for 3D-dSTORM imaging of mouse brain sections to analyze presynaptic active zones, finding differences in Bassoon cluster size and density across hippocampal regions.

The paper investigates presynaptic homeostatic potentiation (PHP) in Drosophila melanogaster, finding that AZs compact rather than enlarge, increasing protein density without changing Brp copy numbers.

The paper identifies DHX36 binding to G-rich mRNA regions and shows it reduces mRNA stability without increasing translation.