Michelle Ninochka D’Souza

This study analyzes ribosomes from wild-type and FMR1 knockout human embryonic stem cells, revealing altered translation rates and rRNA methylation patterns linked to FMRP's role in translational regulation.

This study shows that FMRP regulates the 2O-methylation pattern of rRNA during neuronal differentiation, which affects protein synthesis and is disrupted in Fragile X Syndrome.

This study identifies the functional roles of FMRP domains in translation regulation, showing that the C-terminus mediates ribosome binding and repression, while domain synergy is needed for granule formation and microtubule association.