Deepak Kumar Nair

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

This study reveals how palmitoylation of PSD95 reorients its domains to promote membrane association and clustering, with lipid composition modulating this process.

The paper develops IntAct-U-ExM to visualize actin networks with super-resolution, showing improved resolution of actin structures in yeast and mammalian cells.

This study shows how nanoscale organization of Bassoon and VGCCs in synapses enables functional adaptability through compositional degeneracy and thermodynamic regulation during synaptic plasticity.

This study shows that deleting SRF in astrocytes creates neuroprotective astrocytes that reduce neuronal damage in mouse models of excitotoxicity and neurodegenerative diseases.

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.

This study identifies the functional roles of FMRP domains in translation regulation, showing that the C-terminus mediates ribosome binding and repression, while domain synergy is needed for granule formation and microtubule association.

This study shows that vinculin's tail domain affects neuronal migration and axon growth through actin interactions, independent of talin.

This study visualizes tRNA and protein synthesis in neurons using fluorescent tRNAs, revealing spatial differences in tRNA motion and GluR-dependent translation up-regulation during LTP.