Thomas Boulin

This study identifies PZLS-1 as a regulator of muscle polarity in C. elegans, showing its asymmetric localization and functional interaction with DSH-1 downstream of Wnt-Ror-Dvl signaling.

This study identifies a membrane potential-independent role for the K2P channel TWK-40 in regulating presynaptic organisation through intracellular potassium levels and interactions with PYK-1 and transcription factors.

The paper functionally validates SK channel variants causing NEDMAB and ZLS3 using C. elegans, showing gain- and loss-of-function effects and establishing C. elegans as a model for mutation validation.

This study identifies a unique sodium permeability in the C. elegans K2P channel UNC-58, driven by an atypical cysteine residue in its selectivity filter, highlighting the need for functional experiments to understand sequence variations in potassium channels.

This study identifies a master neuron in C. elegans that modulates forward and backward movement through tonic and phasic activity at different timescales.

This study identifies TWK-40, a K2P channel, as essential for regulating rhythmic motor activity in C. elegans by modulating DVB neuron function and Ca2+ oscillations.

The paper demonstrates that using co-CRISPR marker genes in C. elegans can lead to hidden genomic rearrangements that affect gene function, emphasizing the need for sequencing co-CRISPR genes after CRISPR editing.

The paper describes a CRISPR/Cas9 strategy for efficient and scarless genome editing in C. elegans using a single sgRNA and a selectable phenotype, enabling precise deletions, reporters, and fusions.