An Itch Receptor Drives Melanoma
Naina Gour, Aishwarya Atakkatan, Moloud Akbarzadeh…·Xinzhong Dong
This study identifies MRGPRX4 as a melanoma driver that promotes invasion, therapy resistance, and an immunosuppressive tumor microenvironment.
Author
Institut universitaire de cardiologie et de pneumologie de QuébecORCID 0000-0002-1752-6741Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Naina Gour, Aishwarya Atakkatan, Moloud Akbarzadeh…·Xinzhong Dong
This study identifies MRGPRX4 as a melanoma driver that promotes invasion, therapy resistance, and an immunosuppressive tumor microenvironment.
Romain Devillers, Benjamin Brisebois, Suparba Roy…·Sabine Elowe
This study identifies ZNF768 as a regulator of E2F1 expression, which drives G0/G1 transition and cell cycle progression, with implications for cancer progression.
Diogjena Katerina Prifti, Annie Lauzier, Chantal Garand…·Sabine Elowe
This study shows TEM4 regulates the cell cycle by controlling G1 progression through modulation of p21waf1/cip1 and cyclin B levels.
Daniel Agudelo, Sophie Carter, Minja Velimirovic…·Yannick Doyon
This paper engineers CRISPR-Cas9 variants from Streptococcus thermophilus to target diverse A-rich PAMs, enabling efficient genome editing in mice.