Xinzhong Dong

This study identifies MRGPRX4 as a melanoma driver that promotes invasion, therapy resistance, and an immunosuppressive tumor microenvironment.

This study identifies Mrgpra6 as a basophil-specific GPCR essential for host defense against helminth infection, showing its role in innate immunity and parasite control.

This paper introduces RGRs, genomic repeats that enable high-resolution single-cell molecular recording, validated in live mice for long-term gene activity tracking.

This study identifies Mrgpra2's role in AD hyperplasia and chronic itch in mice, showing its deletion reduces scratching and related symptoms.

This paper develops a mouse model of classical trigeminal neuralgia by intradural nerve root compression, showing neuropathic pain behaviors and pharmacological responsiveness.

This paper demonstrates that transplanting CD200-high hPSC-derived nociceptors reduces pain and promotes joint repair in osteoarthritis by acting as decoys for inflammatory ligands and secreting reparative factors.

The paper uses single-cell sequencing to study immune cell development in the choroid plexus, showing B cell maturation and mast cell regulation impact brain development.

This study identifies the proton-activated chloride channel as a regulator of phagosome maturation and bacterial killing in peritoneal macrophages, showing its role in immune responses.

This study shows that IgG in fibromyalgia syndrome activates mast cells via Mrgprb2, leading to hypersensitivity and inflammation.

The paper develops a computational method to design diverse venom libraries and discovers peptides targeting the human itch receptor MRGPRX4.

The paper demonstrates that human amniotic membrane products inhibit post-surgical pain in mice through CD44-dependent pathways and cytoskeleton rearrangements in nociceptive neurons.

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

This study identifies NGF-TrkA-PI3K signaling in keratinocyte-nociceptor interactions as a driver of obesity-induced small fiber neuropathy and suggests targeting these interactions as a therapeutic strategy.

The paper identifies TRPV1+/MrgprA3+ prurioceptors and Piezo2 channel signaling as drivers of pruritogen-induced alloknesis.

This study uses single-cell RNA sequencing to identify dysregulated fibroblast subclusters in prurigo nodularis, linking them to cancer-associated fibroblast-like phenotypes and increased cancer risks.

This study identifies biliverdin reductase (BVR) as a bridge between FAK/Pyk2 and Src, showing its role in synaptic signaling and learning/memory deficits in BVR-null mice.

The paper investigates pruriception and neuronal coding in nociceptor subtypes in humans and nonhuman primates, finding differences in pruritogen activation and responses compared to rodents.

This study identifies MrgprA3 and MrgprC11 as functional receptors on bladder afferents that induce hypersensitivity to distension when activated, offering a potential therapeutic target for bladder disorders.

This study shows that neuronal EZH2 regulates neuronal morphogenesis and cognitive behavior in mice by controlling gene expression and dendritic spine density.

This study uses high-speed videography and machine learning to objectively assess mouse pain state through paw withdrawal reflex parameters.

This study uses in vivo calcium imaging to show that DMM surgery increases the number of sensory neurons responding to mechanical stimuli in mice, indicating neuronal sensitization.