Author

Sarah Leach

University of Colorado AnschutzORCID 0000-0002-1872-6446Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Angad P. MehtaiD· 1 shared Camille Merrick· 1 shared Diego J. Orea· 1 shared Dustin L. Heiden· 1 shared Graeme Lindsey· 1 shared Hui XuiD· 1 shared Imali Kegode· 1 shared Jenna J. GuthmilleriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperSynthetic Biology

Angad P. MehtaORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMay 29, 2026

Structure informed xrRNA2 mutations in Zika virus provide a roadmap for vaccine development

Camille Merrick, Imali Kegode, Sarah Leach…·John David Beckham

This study introduces structure-informed mutations in ZIKV xrRNA2 to attenuate the virus and evaluate its potential as a vaccine, finding reduced virulence and complete protection in mice.

DOI 10.64898/2026.05.27.728262

mouseexperimental assay

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintDec 24, 2024

Virus-free continuous directed evolution in human cells using somatic hypermutation

Stanley Bram, Diego J. Orea, Graeme Lindsey…·Angad P. Mehta

This paper develops a continuous directed evolution platform in human B cells using somatic hypermutation to evolve proteins with diverse mutations.

2 citations

humanCRISPR screen

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