Youxing Jiang

This study reports cryo-EM structures of rat NCLX in different states, revealing its ion exchange mechanism and structural similarities to NCXs.

This study identifies the molecular mechanism of Necrocide 1 activation of human TRPM4 and explains its species-specific selectivity using cryo-EM, electrophysiology, and cell death assays.

This study presents cryo-EM structures of human NCX1 with PIP2 and SEA0400, revealing how these molecules modulate NCX1 activity through conformational changes.

This study identifies allosteric mutations and lipid interactions that modulate TRPML1 channel function, revealing structural insights into its regulation by lipids and potential therapeutic targets.