Andrew J. Dannenberg

This study shows that SDX-7320, a METAP2 inhibitor, reduces obesity-accelerated tumor growth in mice through both direct anti-tumor effects and indirect metabolic improvements.

This paper characterizes SDX-7320, a MetAP2 inhibitor, showing reduced CNS toxicity and improved pharmacokinetics compared to previous fumagillin derivatives.

The paper identifies stress-induced submitochondrial protein translocation as a mechanism regulating thermogenesis and obesity by mobilizing proteins from the mitochondrial inner membrane into the matrix.