Amy E. Spens

BioBloom enables whole-genome barcoded saturation mutagenesis in E. coli, identifying beneficial mutations under salt and antibiotic selection with high coverage and efficiency.

This study shows DUX4 and mouse Dux interact with STAT1 and inhibit IFN-gamma-induced ISG expression by reducing STAT1 and Pol-II recruitment.

The paper shows that two PREs near the vestigial gene have distinct roles in gene activation and chromatin modification, challenging the idea that PREs solely repress gene expression.