Sylvie Georgeault

The paper presents the first high-resolution structure of a conjugative pilus tip from the R388 T4SS, revealing a structural mechanism that couples tip contact to channel opening and identifies convergent principles in bacterial secretion systems.

This study reports cryo-EM structures of hibernating ribosomes from four Gram-negative bacteria, revealing how hibernation factors inhibit translation.

The paper develops two biosensors in Pseudomonas aeruginosa to detect trans-translation inhibitors, validated through gene deletions and complementation, and demonstrates their use in screening antibiotics and inhibitors.