Michał Rychłowski

This study identifies β4-integrins as critical for maintaining nuclear mechanics and integrity in prostate cancer, linking cell-ECM adhesion to genome stability and patient survival.

This paper demonstrates that light-activated gallium porphyrins can eliminate intracellular MRSA in keratinocytes, reducing bacterial adhesion and infection without significant cytotoxicity.

The paper shows that micronuclei formation during chromatin bridge resolution in prostate cancer cells leads to emerin pauperization from the nuclear envelope, enhancing cell migration and invasiveness.

This study shows Hsp110 NEF enhances Hsp70 disaggregation of protein aggregates, particularly with Class B JDPs, and disrupts JDP-Hsp70 interactions to modulate disaggregation efficiency.

This paper develops IGF2-based LYTACs for lysosomal degradation of extracellular and transmembrane proteins, showing enhanced in vitro effects compared to anti-PD-L1 antibodies.