Robert H. Blelloch

This study develops an inducible system to study enhancer activation in ESCs and shows that KMT2C/D amplify GRHL2-driven enhancer activation.

This study shows that miR-290 and miR-302 clusters are essential for reprogramming fibroblasts to iPSCs, but individually are not required, while their combined loss blocks the process.

This study shows that cohesin is not always necessary for enhancer function, as some enhancers can act independently through synergy or insulators.

The paper shows that coordinated regulation of the Pfn2 transcript by microRNAs and RNA binding proteins is essential for ESC differentiation into germ layer lineages.

This study shows PVRL2 suppresses anti-tumor immunity independently of PVRIG and TIGIT, with deletion reducing tumor growth more than PD-L1 loss.

This study creates a comprehensive single-cell atlas of the maternal-fetal interface, identifying cell-type-specific dysregulation in pregnancy complications.

The paper identifies MLL3/MLL4 enzymatic activity as a regulator of DNA replication timing through H3K4me1 modification, showing its role in chromatin structure and replication dynamics during differentiation.

This study shows that MLL3/4 are essential for dynamic enhancer histone modifications but not for stable ones, and their loss does not impair transcriptional activation of nearby genes.

The paper uses single-cell RNA sequencing to identify a novel cytotrophoblast population in the smooth chorion of the human placenta that functions as a barrier and restricts EVT invasion.

This study identifies a miR-290-PFN2 axis that regulates endocytosis and ERK signaling, affecting ESC self-renewal and differentiation.

The paper investigates the role of DDX6 in linking microRNA functions to mRNA stability and translation in ESCs, finding that DDX6 loss separates microRNA's translational repression from transcript destabilization.