Cell BiologybioRxivPreprint
Transmembrane-domain-driven heterodimer assembly licenses integrin head-domain folding in the endoplasmic reticulum
Jakob M. Reber, Dharmendra Pandey, Hannelore Meyer…·Shiny Shengzhen Guo
This study shows that transmembrane domain interactions in integrin β1-subunit are essential for proper folding and surface expression, with mutations disrupting these interactions causing functional impairments and embryonic lethality.
DOI 10.64898/2026.10.25.761699