Stephen Lockett

This study identifies E-cadherin/YAP-dependent pyruvate carboxylase expression as a metabolic driver of breast cancer progression and metastasis, with therapeutic implications for epithelial TNBC.

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

This study shows TRAIL treatment of TNBC cells activates the NFKB2 pathway, leading to cytokine production that enhances neutrophil chemotaxis and immune suppression.

SPAC provides a scalable platform for end-to-end single-cell spatial analysis of multiplexed tissue imaging data, enabling efficient processing and visualization of large datasets.

The paper identifies spatial interactions between NOS2, COX2, and T-effector cells in ER- breast cancer, linking these patterns to poor patient outcomes and suggesting potential therapeutic strategies.

This study identifies NOS2 and COX2 as key spatial targets in ER- breast cancer that influence immune phenotypes and clinical outcomes through spatial analysis of tumor microenvironments.