Jennifer A. Cobb

The paper develops a nanobody that selectively blocks EFR3 recruitment of PI4KA by targeting TTC7B, reducing membrane recruitment and PI4P production.

This study shows that Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks, promoting resection and accurate repair.

This study shows that loss of Dna2 nuclease activity reduces Exo1-mediated resection at DNA double strand breaks, leading to increased NHEJ and decreased HR.

The paper investigates the role of intrinsically disordered regions (IDRs) in nucleoplasmin-like histone chaperones, finding that some functions require IDRs while others do not.

This study shows that lysolipid treatment alters NE lipid composition, reducing Sir4 telomere association and triggering lipid-specific transcriptional changes in yeast.

This study shows that aging leads to decreased DNA resection and increased end-joining repair, resulting in more genomic mutations in yeast.

The paper investigates the role of Nej1's C-terminus in DNA double-strand break repair pathway choice and end-joining, identifying key residues that influence NHEJ and inhibit resection.

The paper identifies Nej1's interaction with Sae2 and its role in inhibiting DNA resection at DSBs, affecting repair pathway choice and outcomes.

The paper models mutations in the Mre11 complex in yeast to show that defects in ATM signaling, rather than DNA repair, are more critical for tumor suppression.

The paper shows Smc5/6 complex functions in rDNA transcriptional silencing and repeat tethering, affecting lifespan independently of Fob1 and HR processing at the RFB.